GamesFPSDoomPower-crazed boffin gets Doom running through the medium of gut bacteriaWhen you purchase through links on our site, we may earn an affiliate commission.Here’s how it works.
GamesFPSDoomPower-crazed boffin gets Doom running through the medium of gut bacteriaWhen you purchase through links on our site, we may earn an affiliate commission.Here’s how it works.
When you purchase through links on our site, we may earn an affiliate commission.Here’s how it works.
(Image credit: id Software)

Doom has had one of the most remarkable afterlives of any game, from the still-thriving modding and speedrunning scenes to the meme-slash-mission of getting this thing running on any and all technology available to humanity. You’ve seenthe pregnancy tests,the Lego brick,the potatoes, the engineers whogot it going on a 1-milliwatt chipwhile sombrely telling us all what serious business this is. Now, it’s time for some cell shading.
Lauren Ramlam is a biology PhD student at MIT, and for the final project of the synthetic biology course had one big idea: let’s get Doom displaying via gut bacteria.Ramlam’s written reportbriefly outlines the history of Doom running via various things, before coming to the inescapable question of whether “biological systems might be engineered to host this classic millennial FPS.”
The theory is relatively understandable: visually compress Doom’s frames, then replicate which pixels are ‘on’ and ‘off’ to approximate those frames via flourescing bacteria. The only bottleneck Ramlam’s project has is a fairly major one, however. The bacteria do this relatively slowly and, after generating each ‘frame’, there is significant lag time before the cells return to their starting state and are ready to display the next frame.
So Ramlam has this display working but, if you wanted to actually play Doom on it, you’ll need roughly 600 years:
“In conclusion, it takes approximately 70 minutes to reach the peak display output of GFP [the fluorescent protein] in an on well, and a total of 8 hours and 20 minutes for the cell to return approximately to the starting state,” says Ramlam. “The framerate for the original Doom is capped at 35 frames/second, and the average playthrough time is ~5 hours. Doing the math, this means that it would take 599 years to run Doom on cells, according to this simulation.”
The biggest gaming news, reviews and hardware deals
More about fpsActivision will send you alarmingly detailed data for every single Call of Duty match you’ve played in the last 4 years if you ask, and players are using it to figure out their mysterious SBMM rankingsThe 11 big FPS games of 2025LatestToday’s Wordle answer for Sunday, January 12See more latest►
More about fpsActivision will send you alarmingly detailed data for every single Call of Duty match you’ve played in the last 4 years if you ask, and players are using it to figure out their mysterious SBMM rankingsThe 11 big FPS games of 2025LatestToday’s Wordle answer for Sunday, January 12See more latest►
More about fpsActivision will send you alarmingly detailed data for every single Call of Duty match you’ve played in the last 4 years if you ask, and players are using it to figure out their mysterious SBMM rankingsThe 11 big FPS games of 2025
More about fps
Activision will send you alarmingly detailed data for every single Call of Duty match you’ve played in the last 4 years if you ask, and players are using it to figure out their mysterious SBMM rankingsThe 11 big FPS games of 2025
Activision will send you alarmingly detailed data for every single Call of Duty match you’ve played in the last 4 years if you ask, and players are using it to figure out their mysterious SBMM rankings
Activision will send you alarmingly detailed data for every single Call of Duty match you’ve played in the last 4 years if you ask, and players are using it to figure out their mysterious SBMM rankings
The 11 big FPS games of 2025
The 11 big FPS games of 2025
LatestToday’s Wordle answer for Sunday, January 12See more latest►
Latest
Today’s Wordle answer for Sunday, January 12
Today’s Wordle answer for Sunday, January 12
Today’s Wordle answer for Sunday, January 12
See more latest►
Most PopularToday’s Wordle answer for Saturday, January 11The Last of Us season 2 trailer is a brief look at a story you should probably just play yourself in AprilLords of the Fallen publisher embraces fear of the DEI boogeyman, says it will not include ‘any social or political agendas’ in its gamesEpic CEO Tim Sweeney says tech leaders are ‘pretending to be Republicans’ to gain favor with Trump, skirt antitrust laws, and ultimately ‘rip off consumers and crush competitors’If you’re trying to convince me your ‘companionship’ robot is ‘lifelike’, maybe don’t rip her face off in the demo videoSquare Enix launches new anti-harassment policy to protect its employees and partners from abusive fansThe Sims begins its 25th anniversary celebration next week with a Behind The Sims episode of news and announcementsPath of Exile 2 numberlord spends 16 straight days killing rare monsters to prove that a stat that makes loot better makes better lootPalestinian developer raises more than $200,000 to make Dreams on a Pillow, a game about the horrors of the 1948 NakbaPiranha Games will lay off employees after Mechwarrior 5: Clans ‘performed below projections’Marvel Rivals’ latest update quietly killed the game’s burgeoning mod scene
Most PopularToday’s Wordle answer for Saturday, January 11The Last of Us season 2 trailer is a brief look at a story you should probably just play yourself in AprilLords of the Fallen publisher embraces fear of the DEI boogeyman, says it will not include ‘any social or political agendas’ in its gamesEpic CEO Tim Sweeney says tech leaders are ‘pretending to be Republicans’ to gain favor with Trump, skirt antitrust laws, and ultimately ‘rip off consumers and crush competitors’If you’re trying to convince me your ‘companionship’ robot is ‘lifelike’, maybe don’t rip her face off in the demo videoSquare Enix launches new anti-harassment policy to protect its employees and partners from abusive fansThe Sims begins its 25th anniversary celebration next week with a Behind The Sims episode of news and announcementsPath of Exile 2 numberlord spends 16 straight days killing rare monsters to prove that a stat that makes loot better makes better lootPalestinian developer raises more than $200,000 to make Dreams on a Pillow, a game about the horrors of the 1948 NakbaPiranha Games will lay off employees after Mechwarrior 5: Clans ‘performed below projections’Marvel Rivals’ latest update quietly killed the game’s burgeoning mod scene
Most PopularToday’s Wordle answer for Saturday, January 11The Last of Us season 2 trailer is a brief look at a story you should probably just play yourself in AprilLords of the Fallen publisher embraces fear of the DEI boogeyman, says it will not include ‘any social or political agendas’ in its gamesEpic CEO Tim Sweeney says tech leaders are ‘pretending to be Republicans’ to gain favor with Trump, skirt antitrust laws, and ultimately ‘rip off consumers and crush competitors’If you’re trying to convince me your ‘companionship’ robot is ‘lifelike’, maybe don’t rip her face off in the demo videoSquare Enix launches new anti-harassment policy to protect its employees and partners from abusive fansThe Sims begins its 25th anniversary celebration next week with a Behind The Sims episode of news and announcementsPath of Exile 2 numberlord spends 16 straight days killing rare monsters to prove that a stat that makes loot better makes better lootPalestinian developer raises more than $200,000 to make Dreams on a Pillow, a game about the horrors of the 1948 NakbaPiranha Games will lay off employees after Mechwarrior 5: Clans ‘performed below projections’Marvel Rivals’ latest update quietly killed the game’s burgeoning mod scene
Most Popular
Today’s Wordle answer for Saturday, January 11
The Last of Us season 2 trailer is a brief look at a story you should probably just play yourself in April
Lords of the Fallen publisher embraces fear of the DEI boogeyman, says it will not include ‘any social or political agendas’ in its games
Epic CEO Tim Sweeney says tech leaders are ‘pretending to be Republicans’ to gain favor with Trump, skirt antitrust laws, and ultimately ‘rip off consumers and crush competitors’
If you’re trying to convince me your ‘companionship’ robot is ‘lifelike’, maybe don’t rip her face off in the demo video
Square Enix launches new anti-harassment policy to protect its employees and partners from abusive fans
The Sims begins its 25th anniversary celebration next week with a Behind The Sims episode of news and announcements
Path of Exile 2 numberlord spends 16 straight days killing rare monsters to prove that a stat that makes loot better makes better loot
Palestinian developer raises more than $200,000 to make Dreams on a Pillow, a game about the horrors of the 1948 Nakba
Piranha Games will lay off employees after Mechwarrior 5: Clans ‘performed below projections’
Marvel Rivals’ latest update quietly killed the game’s burgeoning mod scene
HARDWARE BUYING GUIDESLATEST GAME REVIEWS1Best Steam Deck accessories in Australia for 2025: Our favorite docks, powerbanks and gamepads2Best graphics card for laptops: the mobile GPUs I’d want in my next gaming laptop3Best mini PCs in 2025: The compact computers I love the most4Best 14-inch gaming laptop: The top compact gaming laptops I’ve held in these hands5Best Mini-ITX motherboards in 2025: My pick from all the mini mobo marvels I’ve tested1Thank Goodness You’re Here! review: An anarchic treasure trove of jokes and skits2Shiren the Wanderer: The Mystery Dungeon of Serpentcoil Island review—like juggling chainsaws on horseback3WD Black SN850X 8 TB NVMe SSD review4Ikea Utespelare desk review5Asus ROG Harpe Ace Mini wireless mouse review
HARDWARE BUYING GUIDESLATEST GAME REVIEWS1Best Steam Deck accessories in Australia for 2025: Our favorite docks, powerbanks and gamepads2Best graphics card for laptops: the mobile GPUs I’d want in my next gaming laptop3Best mini PCs in 2025: The compact computers I love the most4Best 14-inch gaming laptop: The top compact gaming laptops I’ve held in these hands5Best Mini-ITX motherboards in 2025: My pick from all the mini mobo marvels I’ve tested1Thank Goodness You’re Here! review: An anarchic treasure trove of jokes and skits2Shiren the Wanderer: The Mystery Dungeon of Serpentcoil Island review—like juggling chainsaws on horseback3WD Black SN850X 8 TB NVMe SSD review4Ikea Utespelare desk review5Asus ROG Harpe Ace Mini wireless mouse review
HARDWARE BUYING GUIDESLATEST GAME REVIEWS1Best Steam Deck accessories in Australia for 2025: Our favorite docks, powerbanks and gamepads2Best graphics card for laptops: the mobile GPUs I’d want in my next gaming laptop3Best mini PCs in 2025: The compact computers I love the most4Best 14-inch gaming laptop: The top compact gaming laptops I’ve held in these hands5Best Mini-ITX motherboards in 2025: My pick from all the mini mobo marvels I’ve tested1Thank Goodness You’re Here! review: An anarchic treasure trove of jokes and skits2Shiren the Wanderer: The Mystery Dungeon of Serpentcoil Island review—like juggling chainsaws on horseback3WD Black SN850X 8 TB NVMe SSD review4Ikea Utespelare desk review5Asus ROG Harpe Ace Mini wireless mouse review
HARDWARE BUYING GUIDESLATEST GAME REVIEWS1Best Steam Deck accessories in Australia for 2025: Our favorite docks, powerbanks and gamepads2Best graphics card for laptops: the mobile GPUs I’d want in my next gaming laptop3Best mini PCs in 2025: The compact computers I love the most4Best 14-inch gaming laptop: The top compact gaming laptops I’ve held in these hands5Best Mini-ITX motherboards in 2025: My pick from all the mini mobo marvels I’ve tested1Thank Goodness You’re Here! review: An anarchic treasure trove of jokes and skits2Shiren the Wanderer: The Mystery Dungeon of Serpentcoil Island review—like juggling chainsaws on horseback3WD Black SN850X 8 TB NVMe SSD review4Ikea Utespelare desk review5Asus ROG Harpe Ace Mini wireless mouse review
HARDWARE BUYING GUIDESLATEST GAME REVIEWS
1Best Steam Deck accessories in Australia for 2025: Our favorite docks, powerbanks and gamepads
1Best Steam Deck accessories in Australia for 2025: Our favorite docks, powerbanks and gamepads
1
Best Steam Deck accessories in Australia for 2025: Our favorite docks, powerbanks and gamepads
2Best graphics card for laptops: the mobile GPUs I’d want in my next gaming laptop
2Best graphics card for laptops: the mobile GPUs I’d want in my next gaming laptop
2
Best graphics card for laptops: the mobile GPUs I’d want in my next gaming laptop
3Best mini PCs in 2025: The compact computers I love the most
3Best mini PCs in 2025: The compact computers I love the most
3
Best mini PCs in 2025: The compact computers I love the most
4Best 14-inch gaming laptop: The top compact gaming laptops I’ve held in these hands
4Best 14-inch gaming laptop: The top compact gaming laptops I’ve held in these hands
4
Best 14-inch gaming laptop: The top compact gaming laptops I’ve held in these hands
5Best Mini-ITX motherboards in 2025: My pick from all the mini mobo marvels I’ve tested
5Best Mini-ITX motherboards in 2025: My pick from all the mini mobo marvels I’ve tested
5
Best Mini-ITX motherboards in 2025: My pick from all the mini mobo marvels I’ve tested
1Thank Goodness You’re Here! review: An anarchic treasure trove of jokes and skits
1Thank Goodness You’re Here! review: An anarchic treasure trove of jokes and skits
1
Thank Goodness You’re Here! review: An anarchic treasure trove of jokes and skits
2Shiren the Wanderer: The Mystery Dungeon of Serpentcoil Island review—like juggling chainsaws on horseback
2Shiren the Wanderer: The Mystery Dungeon of Serpentcoil Island review—like juggling chainsaws on horseback
2
Shiren the Wanderer: The Mystery Dungeon of Serpentcoil Island review—like juggling chainsaws on horseback
3WD Black SN850X 8 TB NVMe SSD review
3WD Black SN850X 8 TB NVMe SSD review
3
WD Black SN850X 8 TB NVMe SSD review
4Ikea Utespelare desk review
4Ikea Utespelare desk review
4
Ikea Utespelare desk review
5Asus ROG Harpe Ace Mini wireless mouse review
5Asus ROG Harpe Ace Mini wireless mouse review
5
Asus ROG Harpe Ace Mini wireless mouse review